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Gastroenterology Thesis (Cairo University)
Discussion Date:2004
Cairo University MSc
Call Number:11612 Tropical Medicine
Thesis Title(s):Correlation between C A 19-9 and alpha fetoprotein (AFP)in diagnosed cases of hepatcellular carcinoma
Researcher Name:Mohammed Abdel Sattar Mohammed Darwesh
Supervisor Name(s):Laila Ahmed Mohammed
Hosny Mohammed Salama
Mohammed Mohammed Tawfik
Abstract:Hepatocellular carcinoma ranks eighth in frequency among cancers worldwide.It's the most common primary malignant tumor of the liver and is the direct cause of about one million deaths annually.HCC is a common malignancy in Egypt and usually develops on top of cirrhosis of viral origin.The aim of this study is to assess the value of CA 19.9 as a tumor marker in the diagnosis of HCC and correlating it with AFP.This study was conducted on sixty patients who were classified into two groups each including 30 patients.The results of this study showed that there is no correlation between the two markers in diagnosed cases of HCC but further studies are to be considered.
Date entered : 12-12-2005
Date updated : 04-02-2007
Discussion Date:2003
Cairo University MSc
Call Number:11175 Tropical Medicine
Thesis Title(s):Three dimensional ultrasonography in the diagnosis of hepatic focal lesions
Researcher Name:Mohamed Abdalla Zakaria
Supervisor Name(s):Nabil El Kady
Gamal Esmat
Maissa El Raziky
Pagination:vii,209,(2)p.: ill.; 25 cm
Abstract:Three dimesional ultrasonography in the diagnosis of hepatic focal lesions focal lesions of liver frequently present diagnostic dilemma especially in patients with different hepatocellular disease.Three dimesional ultrasonography has been recently introduced and is being evaluated in the diagnosis of HFL.24 patients with different HFL were subjected to full clinical assessment,routine labs and abdominal ultrasound by both conventional and 3Dtechniques conclusions : 3D ultrasound showed the following,it represents a further development of non -invasive diagnostic sonographic techniques,it improves understanding the morphologic imaging methods,it has the ability to obtain ultrasound sections which are impossible to see on routine scan,it has the ability to perform accurate volume measurements,it clarifies pictures ofvascular and blood flow dynamics allowing a better assessment of vasculature and vascular invasion,by using the 3D power Doppler it can be helpful in differential diagnosis of hepatic focal lesions as well as evaluation of tumoural vascularity and the 3D color histogram was applied to measure the colour percentage and flow amplitude in the volume of hepatic focal lesions.
Date entered : 12-14-2005
Date updated : 04-02-2007
Discussion Date:2003
Cairo University MSc
Call Number:11407 Tropical Medicine
Thesis Title(s):Clinical value of total H.C.V core antigen detection and quantification as a new marker of H.C.V.replication
Researcher Name:Ayman Mohamed Abdel-Aziz
Supervisor Name(s):Ahmed Abdel-Latif Abu Madian
Laila Ahmed Mohamed
Mahmoud Mohamed Omar
Pagination:(7), 188,(3)p.: ill.; 26 cm
Abstract:Recently,the availability of total HCV core antigen assay in peripheral blood gains more interest in clinical evaluation of Hepatitis C Virus patients.The aims of the present study were to assess the value of total HCV core antigen as a marker of viral replication,to determine the sensitivity of core antigen assay relative to molecular biology technique and to study the clinical value of HCV core antigen in relation to interferon-based treatment.This study included 150 patients sero-positive for antibodies to HCV.Viral load was assessed by both HCV RNA quantitative assay (bDNA)and HCV core antigen quantitative immunoassay (Ortho trak-C assay). Spearman rank correlation coefficient was used to determine significant correlations among parameters.Of the 150 studied patients,128 (85)were positive to HCV RNA assay (bDNA)and 22 (15)were negative.Have the 128 patients tested positive for HCV RNA,125 patients tested positive by HCV core antigen assay with a sensitivity of 98.All patients tested negative for HCV RNA assay (bDNA)gave negative results by HCV core antigen assay with a specificity of 100.In the 125 patients that were positive in both assays,HCV RNA and total HCV core antigen were significantly related (r = 0.984;p 0.001). The relationship between HCV RNA in IU/ml and total HCV core antigen in pg/ml was given by the following equation:Log HCV core antigen
Date entered : 12-15-2005
Date updated : 04-02-2007
Discussion Date:2004
Cairo University MSc
Call Number:11512 Tropical Medicine
Thesis Title(s):The Value of doppler ultrasography in the assessment percutaneeous ablative therapies (PATS)of hepatocellular carcinoma
Researcher Name:Rabab Mohammed Maher
Supervisor Name(s):Nabeel Moustafa El-Kady
Hanan Abdel Haleem
Ayman Rashad Amer
Pagination:xiii,247 p.: ill., diagrs;25 cm
Abstract:Hepatocellular carcinoma (HCC)is the most common primary liver cancer and has a world wide distribution.Interventional procedures for percutaneous tumor ablation have an increasingly important role in the treatment of liver malignancy.After interventional therapies,noninvasive vascular diagnostic imaging (such as : Duplex,Color and Power Doppler Sonography and spiral C.T)have the key role to determine if the treated lesion is completely ablated or contains area of residual viable neoplastic tissue This is particularly important since in cases of incomplete necrosis of the lesions,treatment can be repeated and tumor ablation can be further pursued.This study was conducted on (30)patients with (33)HFLs proved to be hepatocellular carcinoma (HCC), to analysis the usefulness of Duplex,color and power Doppler sonography in the assessment of tumor vascularity after percutaneous ablative therapies (PATs). Residual Doppler signals in the tumor after (PATs)were related to residual viable tumor cells.However absence of signals does not indicate complete ablation.
Date entered : 12-18-2005
Date updated : 04-04-2007
Discussion Date:2004
Cairo University MD
Call Number:11582 Tropical Medicine
Thesis Title(s):Plasma and hepatic tissue endothelin-1 level in liver cirrhosis with and without bleeding esaphageal varices
Researcher Name:Mohamed Darwish El-Talkawy
Supervisor Name(s):Zakaria Abdel-Latif Salama
Moataz Hassan Hassanein
Mohamed EL-Khodary
Pagination:v,1923,(3)p.: ill.; 25 cm
Abstract:Portal hypertension is characterized by a pathological increase in portal pressure,and often leads to the formation of esophageal varices and ascites.Bleeding esophageal varices were found to be responsible for more than half of cases presenting by upper gastrointestinal hemorrhage.The potent vasoconstrictive peptide,Endothelin-1 (ET-1)is increased in liver cirrhosis suggesting a possible role for this vasoactive peptide in the pathogenesis of portal hypertension.This study was designated to determine circulating and hepatic tissue ET-1 in Egyptian patients with and without bleeding esophageal varices dou to liver Cirrhosis.Plasma and hepatic tissue endothelin-1 were detected in our study by ELISA technique in Seventy-five individuals.Our result shows a significant increase of plasma and hepatic tissue Endothelin-1 in bleeding esophageal varices duo to liver cirrhosis.
Date entered : 12-18-2005
Date updated : 04-04-2007
Discussion Date:2003
Cairo University MSc
Call Number:11315 Tropical Medicine
Thesis Title(s):Prevalence of helicobacter pylori infection in patients undergoing upper gastrointestinal endoscopy in the Police Hospital and a five years retrospective study of the magnitude of gastric pathology for patients who presented to gastrointestinal unit in Kasr El-Aini Hospital.
Researcher Name:Khaled Mamdouh Gabr
Supervisor Name(s):Fouad Thakeb
Wahid Doss
Medhat El Sahhar
Pagination:v,174,(2)p.: ill., diagrs;26 cm
Abstract:Background:The discovery of H pylori in 1983 by Marshall and Warren and establishment of its role in gastroduodenal ulcers and gastric neoplasms has caused a paradigm shift in the understanding and management of these diseases.In 1994,H pylori has been classified by WHO as a group I carcinogen.Subjects and Methods:This work comprises two separate arms the first one,a prospective study with the aim of estimating the prevalence of Helicobacter pylori among a group of Egyptian patients presenting with upper gastrointestinal symptoms and to delineate the common symptoms and endoscopic findings that might be associated with Helicobacter pylori infection.The second arm of this work,a retrospective epidemiological study involving the analysis of the endoscopic findings of patients presented to the gastrointestinal endoscopy and liver unit at Kasr El-Aini hospital over the last five years in an attempt at evaluation of the chronological difference in the gastric pattern diagnosed endoscopically over that time period.Results:From the 800 cases of the police hospital 684 (85.5)of them showed positive Clo test for H pylori infection with a male predominence (86.7)and that the greatest affection was in the middle age group.Gastric malignancy patients showed the highest prevalance (100)followed by patients with peptic ulcer (91.6). For the second part of this study it was conducted on 7262 patients who underwent upper endoscopy at Kasr El-Aini endoscopy unit and showed also a male predominense (61.3)and the most detected endoscopic finding was gastritis.No significant changes were found in the pattern of gastric pathology through the last 5 years.Conclusion:The prevalence of Helicobacter pylori in Egypt is very high and it affects mainly the middle age group with highest activity and productivity and this could have a further socioeconomic impact when added to the health problems this microorganism could cause.The gastric pattern over the last five years showed no significant changes regarding the different endoscopic gastric lesions.
Date entered : 12-18-2005
Date updated : 04-04-2007
Discussion Date:2003
Cairo University MSc
Call Number:11182 Tropical Medicine
Thesis Title(s):Polyethylene biliory blockage : a morphological and bacteriological study
Researcher Name:Ahmad Abdalla Negm
Supervisor Name(s):Ayman Yosry Abdelraheem
Hisham Raafat El-Khayat
Rabab Fouaad Emam
Pagination:175,(2)p.: ill., diagrs;26 cm
Abstract:Two thirds of patients with biliary obstruction before decompression are at high risk of bacterial cholangitis even without presence of symptoms with Gram -ve organisms being the most incriminated in bacterial cholangitis especially the Enterobacteriaceae family.All the recovered organisms are capable of elaborating number of biologically active enzymes."Incidence of cholangitis is higher in presence of the stents than before biliary decompression."Gram -ve organisms are strongly indulged in the pathogenesis of plastic stent blockage with microbiological and electron microscopic documentation.
Date entered : 12-18-2005
Date updated : 04-04-2007
Discussion Date:2003
Cairo University MSc
Call Number:11264 Tropical Medicine
Thesis Title(s):Early diagnosis of HCC
its differentiation form other hepatic space occupying lesions
Researcher Name:Ashraf Salah H.Abou El-Hawa
Supervisor Name(s):Sameh Saad Labib
Moh.Ibrahim Abdel Hamid
Pagination:251,(3)p.: ill., diagrs;25 cm
Abstract:This study includes 103 patients with different hepatic space occupying lesions at high risk of developing HCC.Thirty seven patients had AFP level between 10.9 400 ng/dl,and 33 patients had levels more than 400 ng/dl.Ultrasonography suggested the diagnosis of HCC in 44 patients,Metastatic liver disease in 7 patients and regenerating nodule in 11 patients.Histopathologicaly the diagnosis of HCC was established in 50 , regenerating nodule in 28.6 and metastasis was detected in 17
Date entered : 12-25-2005
Date updated : 04-04-2007
Discussion Date:2003
Cairo University MD
Call Number:10983 Tropical Medicine
Thesis Title(s):Comparative study between percutaneous ethanol injection and radiofrequency thermal ablation in treatment of hepatocellular carcinoma
Researcher Name:Mohammed Mahmoud Nabeel Yusuf
Supervisor Name(s):Nabeel Mostafa El-Kady
Gamal El Din Esmat Gamil
Iman Isamil Ramzy
Pagination:225,3 p.: ill.; 26 cm
Abstract:This study included two groups of patients with HCCs 5 cm in diameter,group A included 21 patients with 28 HCCs and group B included 29 patients with 30 HCCs.Group A patients were treated by percutaneous ethanol injection,while group B patients were treated by radiofrequency ablation.The results of treatment were assessed by AFP,liver biopsy,Power Doppler and Spiral C.T.which proved the efficacy of PEI to produce complete ablation of the malignant cells in larger number of cases than those treated with RFA (96.4 Vs 73.3)P0.05.After the follow up of all patients for at least 6 months,the survival rate was (90.5,45.4,30)for group A patients and was (72.4,48,36.4)for group B patients at 6,12 and 18 months respectively.
Date entered : 12-25-2005
Date updated : 04-04-2007
Discussion Date:2003
Cairo University MSc
Call Number:10784 Tropical Medicine
Thesis Title(s):Prevalence of barrett's oesophagus among patients with reflux oesophagitis
Researcher Name:Samar Sami Ali
Supervisor Name(s):Fouad Ibrahim Thakeb
Eliya Anis Ishak
Ashraf Omar Abd El-Aziz
Pagination:iii,185,2 p.: ill., diagrs;26 cm
Abstract:Barrett's oesophagus,a complication of gastro-oesophageal reflux disease,is the replacement of squamous tissue with specialized intestinal metaplasia.The aim of the study was to determine the prevalence of Barrett's oesophagus among Egyptian patients with reflux oesophagitis.Results:The study was done on 132 patients (31 females and 101 males)who suffered from GIT symptoms of reflux.It was found that the prevalence of Barrett's oesophagus in our patients was 16.7 of cases.
Date entered : 01-14-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:10908 Tropical Medicine
Thesis Title(s):Effects of DDB monotherapy and in combination with amontadine hydrochloride and ribavirin in patients with chronic hepatitis C virus infection
Researcher Name:Wael Fathy El-Sayed
Supervisor Name(s):Hosny Mohammad Salama
Ayman Rashad Amer
Osama Mohammad Hammad
Pagination:112,(2)p.: ill., diagrs;26 cm
Abstract:DDB is a chinese hrebal treatment used in treatment of hepatitis B,the aim of this work is to assess its efficacy and safety alone and in combination with amantadine and ribavin in patients with chronic HCV for 3 months.It was found effective in lowering AST and normalization of ALT in all patients with no effect on viremia and mild side effects.Addition of anti viral agents to DDB proved to decrease viremia and even clearance of viremia in 10-15of patients with mild side effects
Date entered : 01-15-2006
Date updated : 04-08-2007
Discussion Date:2004
Cairo University MSc
Call Number:11493 Tropical Medicine
Thesis Title(s):Serum angiotensin II and angiotensin converting enzyme in Egyptian patients with chronic liver disease
Researcher Name:Eman Mohammed Hassan Sharshar
Supervisor Name(s):Afaf Farrag
Yasser Al Boraey
Nagwa Kamal Eldin Saad
Pagination:(3), 140 p.: diagrs;25 cm
Abstract:This study was done to assess the serum level of ACE and plasma level of angiotensin II in patients with chronic liver disease and to correlate these levels with the degree of portal hypertension,the presence of ascites and renal function.This study included 59 patients (40 males and 19 females)and 19 healthy age and sex matched controls.Patients with post hepatitic chronic liver disease were included in this study and were;16 patients with uncomplicated chronic liver disease (group A), 11 patients with liver cirrhosis and portal hypertension without ascites (group B), 21 patients with portal hypertension and ascites (group C)and 11 patients with hepatorenal syndrome (group D). Patients were subjected to full medical history and clinical examination,abdominal ultrasonography,upper endoscopy with grading of oesophagogastric varices,laboratory evaluation including liver and kidney function tests,creatinine clearance,serum and urinary electrolytes,in addition to assessment of plasma level of angiotensin II by radioimmunoassay (RIA)and serum level of ACE by kinetic method.It was found that the mean values of serum ACE and plasma angiotensin II increased significantly from group A to D and it was found that their values in group B and group C were nearly similar but were higher than group A.Values in group D were higher than other groups.There was significantly negative correlation between the values of ACE and angiotensin II and each of blood pressure,serum sodium,urinary sodium,urinary creatinine and creatinine clearance.On the other hand,there was significantly positive correlation between the values of ACE and angiotensin II and each of PV diameter,grade of varices,degree of ascites,serum creatinine,blood urea and serum bilirubin,while the highly significantly positive correlation was between serum ACE and plasma angiotensin II values and between their values and Child Pough classification and this indicates that their values increase with the severity of liver disease.
Date entered : 01-19-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MD
Call Number:10916 Tropical Medicine
Thesis Title(s):The Role of cytokines in ulcerative colitis
Researcher Name:Hossam Sabry Ghoneim
Supervisor Name(s):Serag Zakaria
Gamal Essmat
Aly El-Hendawy
Pagination:310,(1)p.: ill., diagrs;25 cm
Abstract:Recently,a series of discoveries in the immuno-inflammatory process have provided new potential targets for diagnosis and treatment of IBD (Inflammatory bowel disease). The role of different cytokines (namely TNF-
IL-2)in the pathogenesis
possibly management of ulcerative colitis (U.C.) was studied.It is found that TNF- indeed did play an important role in pathogenesis
was abundant in colonic biopsies of patients with U.C.compared to other patients in normal subjects whereas IL-2 was apparently not significant,an issue which is of controversy in literature.Therefore,anti-TNF- drugs could play a role in management.
Date entered : 01-21-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:11203 Tropical Medicine
Thesis Title(s):The Role of three-dimensional ultrasono-graphy in The diagnosis of atients with splenic focal lesions
Researcher Name:Waleid Abd El-Fatah El-Wasef
Supervisor Name(s):Nabil Moustafa Khalil El-Kady
Iman Ismail Ramzy
Hanan Abd El-Haleem Marzouk
Pagination:214 p.in various paging : ill.; 26 cm
Abstract:Professor Dr.Nabil El-Kady,Dr.Iman Ramzy,and Dr.Hanan Abd El-Haleem,Tropical Medicine Department,Cairo University.Twenty patients with splenic focal lesions diagnosed by ultrasonography were included in this study 11 of them were males and 9 females.Their ages ranged from 9 - 73 years with a mean of (35.05 + 17.85). Ultrasound guided aspiration and/or biopsy was / were performed with histopathological assessment of the specimens.The histopathological examination of the splenic focal lesions revealed that malignant lymphomas were the most common one,fifty percent of the patients were found to have malignant lymphoma,60of them were non-Hodgkin's lymphoma,while the remaining 40 were Hodgkin's disease.Pyogenic splenic abscesses were present in 15(N = 3), all of them had leucocytosis with shift to the left.By ultrasonographic examination the lesions were found to be single in (67)with hypoechoic pattern in (67 ) of the patients.Simple splenic cysts were present in (N = 2 10)of the cases.By ultrasonographic examination they were single focal lesion (100)with an anaechoic echopattern.Hydatid disease was present in one of these cases (5). The remaining diagnosis were solid lesions (metastases)or cystic lesions (hematoma,hemangioma and infarction)each comprising 5.ultrasonographic guided needle aspiration was done in all cystic lesions,core biopsy was done in all solid lesions.On comparing both results,sensitivity of core biopsy was 100while that of aspiration was 89.Three dimensional ultrasonography was done on 20 patients,the site,number and echogenicity was found to be the same as those detected by two dimensional ultrasonography.Volume of splenic focal lesions was measured by three dimensional ultrasonography and was compared with volume measured by two dimensional ultrasonography.The volume measured by 3 DUS was found to be significantly smaller,P = 0.008.In cystic lesions 40(n=8)the volume measured by 3 DUS was found to be non significantly smaller,(P 0.05). In solid lesion 60(n = 12)the volume measured by 3 DUS was found to be significantly smaller,P = 0.0058.From this study it can be concluded that the volume measured by 3 DUS was significantly smaller than volume measured by 2 DUS
Date entered : 01-26-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:11134 Tropical Medicine
Thesis Title(s):Evaluation of liver tissue polymerase chain reaction for hepatitis B virus in patients with negative viraemia
Researcher Name:Raghda Nabeel A.Marzaban
Supervisor Name(s):Fouad Ibrahim Thakeb
Magdy Amin El-Serafy
Mostafa Kamel El- Awady
Pagination:206,(3)p.: ill.; 26 cm
Abstract:In our study,we aimed at evaluating the clinical significance of localization of HBV DNA in liver.PCR test was performed for HBV DNA in both serum and liver.It was evaluated in relation to the clinical,serological and histological parameters.HBV constituted 6.6 among chronic liver diseases,78.8 were HBeAg negative.We discovered a new category of patients constituted 30.3 characterized by negative viraemia and positive HBV DNA in liver.We suggested to name it "Hepatitis B In Situ" and we recommend such patients to be treated.
Date entered : 02-05-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:10674 Tropical Medicine
Thesis Title(s):Correlation of ultrasonographic findings with histopathological diagnosis in HCV related chronic liver diseases
Researcher Name:Mohamed Ahmad Ali Al-Dhafari
Supervisor Name(s):Gamal Al-Deen Esmat Mohamed
Hany Mahmoud Khattab
Maissa El-Said El-Raziky
Pagination:ix,152,2 p.: ill.; 25 cm
Abstract:This study investigated the accuracy of ultrasonography and duplex-Doppler in predicting the final diagnosis in 80 patients with compensated HCV related chronic liver disease in comparison to histopathological diagnosis which revealed.A highly significant positive correlation between liver surface and fibrosis stage and a significant negative correlation between portal vein peak velocity and fibrosis stages.There was a highly significant correlation between left lobe span (in ML)and splenic size with steatosis grades.There was a significant positive correlation between quadrate lobe (TD)and liver texture and presence of HDLN with steatosis grades.There was a significant positive correlation between right lobe span (in MCL)and HAI,also there was a significant negative correlation between HA resistive index and HAI.
Date entered : 02-06-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MD
Call Number:10870 Tropical Medicine
Thesis Title(s):Predictive factors of response in the treatment of hepatocellular carcinoma by radiofrequency versus acetic acid injection
Researcher Name:Ahmad Fouad Mohamad Soliman
Supervisor Name(s):Soheir Zakria Eissa
Gamal Esmat Gamil
Ashraf Omar Abd-Al Aziz
Pagination:xi,270,2 p.: ill.; 25 cm
Abstract:This study was performed on 57 patients having liver cirrhosis with 63 focal hepatic lesions detected by ultrasound and proved histopathologically to be HCC by ultrasound guided biopsy and/or fine needle aspiration cytology.They were 50 males and 7 females their ages ranged between 37 and 75 years old.Patients were classified randomly into two groups.Group A was formed of 32 patients with 37 focal lesions where they received RFA.Group B encountered 25 patients with 26 focal lesions and they received PAI.As regard the outcome of therapy in group A,complete ablation was achieved in 14/18 (78)lesions ? 3 cm.For lesions ranging between 3.1-4 cms,complete ablation occurred in 7/11 (64)lesions and lastly 4/6 lesions ranging between 4.1-5 cms were completely ablated.There was no size range with more favorable outcome in group B,complete ablation for lesions ? 3 cms occurred in100of cases while in lesions ranging between 3.1-4 cms it was achieved in 8/9 (89)of the lesions.For lesions ranging between 4.1-5 cms complete ablation was achieved in 5/7 (71.4)lesions.Again here there was no size range with more favorable outcome.On comparing the outcome of both techniques the overall success in group A was 71.4while in group B it was 88.4with no significant statistical difference (P value= 0.13). As regard the number of sessions in each group,the mean number of sessions in group A was 2.2 while in-group B it was 2.19 with P value 0.72.As regard complications,major complications occurred in group A only in 4 patients.One patient developed an attack of haematemesis,another one developed second degree burn at the site of grounding pads,the third developed pneumothorax and the fourth developed malignant pleural effusion.Minor complications occurred in both groups but it was more evident in group B.Pain occurred in 44of cases in group A and in 84of cases in group B.Fever was reported in 6 of cases in group A and in 56of cases in group B.Lastly ascites occurred in 1 case (3.1)in group A and 4 cases (16)in group B.
Date entered : 02-14-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MSc
Call Number:10400 Tropical Medicine
Thesis Title(s):Clinlcal significance of transforming growth factor-beta1in the diagnosis of hepatocellular carcinoma associated with HCV infection
Researcher Name:Waleed Fouad Fathalah
Supervisor Name(s):Laila Ahmed Mohammed
Olfat Gamil Shaker
Hanan Abd El Halim Marzouk
Pagination:viii,231,(2)p.: ill., diagrs;25 cm
Abstract:Hepatocellular carcinoma is a serious complication of chronic liver disease.Serum AFP levels have been reported to be elevated above the upper limit of normal values in only 33-65 of patients with HCC.Patients with HCC (20)showed significant higher serum TGF- 1 levels than those in the patients with chronic hepatitis and cirrhosis as well as in normal control (p-value 0.01). Sensitivity of TGF- 1 was 90 and the specificity was 100 at the cut off level of 130 pg/ml whichis much higher than AFP (sensitivity 35 at cut off 400 ng/ml)
Date entered : 02-21-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:10399 Tropical Medicine
Thesis Title(s):Role of endosonography in the evaluation of pancreatic diseases
Researcher Name:Mohamed hamed Abdel Hamid
Supervisor Name(s):Zakaria A Salama
Asmaa Abou Rabia
Mohamed Ibrahim
Pagination:iv,189,(20)p.: ill.; 25 cm
Abstract:The present work was conducted on 20 patients twelve males
eight females with age ranging from 19-71 years presenting with clinical,laboratory or imaging studies suggestive of pancreatic disease.Abdominal ultrasound,CT and endosonography were done to all the patients.Abdominal ultrasound diagnosed a pancreatic lesion correctly in only 10 patients,while CT showed a pancreatic lesion in 18 cases and 2 were free,finally endosonography revealed a pancreatic lesion in 19 patients and in 1 patient the pancreas was free.By EUS 55 and 40 were diagnosed as cancer pancreas and pancreatitis respectively.The efficacy of endoscopic ultrasound compared to computed tomogarphy and abdominal ultrasound was evaluated in patients either by follow up or by surgery whenever possible,based on histopathological examination.From this study we can conclude that endosonography is sensitive in diagnosing pancreatic diseases.
Date entered : 02-21-2006
Date updated : 04-08-2007
Discussion Date:2003
Cairo University MSc
Call Number:10828 Tropical Medicine
Thesis Title(s):Serum ferritin and reduced glutathione concentrations in chronic hepatitis C Patients treated with interferon-alpha
Researcher Name:May Ismail Mehrez
Supervisor Name(s):Afaf Farrag
Hanan Abd El-Haleem
Hanan Hossney
Pagination:217,(2)P.: ill.; 25 cm
Abstract:Introduction:Viral hepatitis C is one of the major health problems worldwide.Combining Interferon alpha with ribavirin in treatment of HCV proved to be the best regimen of treatment,yet it has a considerable percent of non-response.Aim:Evaluation of the relation between serum ferritin levels and erythrocytic reduced glutathione concentration,in chronic hepatitis C patients treated with combination therapy,and response to treatment.Methods:The study included 40 patients (20 responders to combination therapy,and 20 non-responders to the same regimen)and another 20 healthy subjects as controls for the comparison between serum ferritin and erythrocytic reduced glutathione with the other 2 groups.Results:On comparison of levels of erythrocytic reduced glutathione between responders (Range:6.3-8.9 M/gHb)and non-responders (Range:3.3-4.5 M/gHb)that it was statistically highly significant (P0.00), but levels in both groups are still lower than the control group (Range:10-15 M/gHb). As regards the comparison of serum ferritin levels between responders (Range:25-200ng/ml)and non-responders (Range:98-643ng/ml), this was statistically highly significant (P0.00). Conclusion:Non-response to combination therapy was associated with increased levels of serum ferritin and decreased levels of erythrocytic reduced glutathione.
Date entered : 02-21-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MD
Call Number:10251 Tropical Medicine
Thesis Title(s):Experimental extracorporeal pioartificial liver support
Researcher Name:Mohamed Saad Zaghloul
Supervisor Name(s):Abdel Latif Abu Median
Moamena Kamel
Moh.Sirag Zakaria
Azza El Adawy
Pagination:viii,294,(2)p.:ill.; 25 cm
Abstract:Background:Fulminate hepatic failure (FHF)is a serious condition with very high mortality.A practical liver support system for patients in (FHF)remains a needed therapeutic modality.An extracorporeal bioartificial liver might be an appropriate treatment,since it can provide liver-specific functions,maintain the patient alive and allow spontaneous recovery of patients own liver or act as bridge toward liver transplantatio Methods:We have established a model of acute liver failure in rats by administration of D-galactosamine.The animal model was used to evaluate a bioartificial liver (BAL)based on viable hepatocytes.We have isolated normal hepatocytes by a modified collagenase perfusion technique from 18 male golden hamsters (150-250 gm). The average viability of hepatocytes in our experiment had been about 90 determined by trypan blue exclusion.Cells were immobilized in a membrane-coated alginate gel beads to form micro-encapsulated hepatocytes,which were subsequently inoculated into the bioreactor.BAL contained 10 ml of hepatocyte suspension with approximately 10.107 viable microencapsulated hepatocytes.80 adult white male rats 6-8 week old (Wt = 150 - 250 gm)were studied.60 rats were administered D-galactosamine (0.5 gm/kg)intraperitoneally and divided into three experimenal groups:positive control group (GII n = 20)received only 20 dextrose infusion (0.2 to 0.7 ml/hr)via venous blood line to prevent hypoglycemia,device control group (GIII n=20)connected to empty BAL and treated group (GIV n =20)connected to BAL with microencapsulated hepatocytes.The other 20 rats did not receive D-gal (normal rats)connected to BAL with micro encapsulated hepatocytes for 2 hours to test safety and tolerability of animals to BAL treatment considered as negative control (GI n = 20). Hemoperfusion through BAL was carried for 2 hours in treated animals 24 hours after injection D-gal.Main outcome parameters were survival,neurologic status and histopathologic exam as well as laboratory parameters (prothrombin time,serum bilirubin,ALT,AST and blood ammonia)were measured at 0,24,48 and 72hrs after injection of D-gal.Results:All experimental animals developed evidence of liver failure at 24hrs after injection of D-gal as evidenced by prolonged prothrombin time,marked hepatocellular enzymes elevation as well as blood ammonia,serum bilirubin and microscopic massive hepatocyte necrosis.Survival of FHF rats connected to BAL with microencapsulated hepatocytes (GIV)was significantly increased when compared to control groups (II and III). 55 of treated animals had survived (p0.001). All BAL treated animals GIV experienced neurological improvement.Histopathology of the animals that died 72hrs of D-gal showed massive centrilobular necrosis.In contrast,the histology of the survived animals in GIV was almost normal when compared to negative control group.All laboratory parameters showed significant improvement in BAL treated GIV when compared to GII,III.Conclusion:D-galactosamine rat liver failure model is effective in testing hepatocyte-based extracorporeal support,which can provide metabolic support,increases survival and allows recovery in rats with FHF.
Date entered : 02-27-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MD
Call Number:10509 Tropical Medicine
Thesis Title(s):Helicobacter pylori infection and antroduodenal motility in patients with non ulcer dyspepsia
Researcher Name:Mostafa Hussein Ibrahim
Supervisor Name(s):Mohamed Shokry Hunter
Effat Ramadan El Sherif
Medhat Hassan El Sahar
Pagination:193,(3)p.: diagrs;25 cm
Abstract:This study aimed to assess whether H.pylori infection has a role in antroduodenal motility in non ulcer dyspepsia patients or not.The interdigestive and post-prandial antroduodenal manometry were studied in (14)patient with non-ulcer dyspepsia (7 patients with H.pylori infection and 7 patients without H.pylori infection)and (14)patients with gastritis (7 patients with H.pylori and 7 patients without H.pylori). The total duration of MMC,the duration of individual phases I,II,III,the antral motility index of phase II,the antral post-prandial motility index and the duodenal motility parameters showed no significant difference between H.pylori positive and H.pylori negative patients.In conclusion H.pylori infection has no effect on antroduodenal motility in patients with non-ulcer dyspepsia.
Date entered : 02-27-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MSc
Call Number:9896 Tropical Medicine
Thesis Title(s):Acute upper gastrointestinal bleeding in Kasr El Aini gastrointestinal endoscopy uint in the last 10 years
Researcher Name:Manal Kamel Gouda
Supervisor Name(s):Gamal Esmat
Wahid doss
Pagination:182,(2)p.: diagrs;25 cm
Abstract:Background:Gastrointestinal bleeding is a common and potentially serious problem,which remain a major reason for hospital admission.Chronic liver disease,portal hypertension and hematemesis are major problems in Egypt due to schistosomiasis and viral hepatitis.Subjects and Methods:This is a retrospective study of 11567 cases referred to Gastrointestinal Endoscopy Unit in Kasr El-Aini Hospital,Cairo University during the last 10 years (1991-2000). Results:From 11567 cases who underwent upper endoscopic examination;1763 (15.2)patients were referred due to upper gastrointestinal bleeding with males predominance (64.5). While most of the cases were in the middle age group we noted that the percentage of the patients who presented with upper gastrointestinal bleeding in the old age group were more than those in the middle age group.The study has shown that the commonest causes of upper gastrointestinal bleeding were esophago-gastric varices (53.3), erosions (41.7)and ulcers (24.9). The majority of the cases (88.9)of upper gastrointestinal bleeding presented by hematemesis and melena and the most common lesion in this group was esophago-gastric varices (56.4)while (11.1)of the cases presented with melena only.Esophago-gastric varices were detected in 18 of non-bleeders group while this percentage was more higher in the bleeders group (53.3). Most of the bleeders group were having large varices (grade III and IV)55.7 and 44.1 of them were having gastric varices.The findings of double upper gastrointestinal tract lesions were found in 30.9 of cases of upper gastrointestinal bleeding.The commonest associated lesions occurring with esophago-gastric varices were gastric erosions,congestive gastropathy and gastritis.Conclusion:Chronic liver disease complicated by portal hypertension and esophago-gastric varices is still a major problem and it is the main etiology of upper gastrointestinal bleeding in Egypt.Peptic ulcerations are the second cause of upper gastrointestinal bleeding in Egypt.
Date entered : 02-28-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MSc
Call Number:10035 Tropical Medicine
Thesis Title(s):Correlation between serum level of nitric oxide and grade of congestive gastropathy in Egyptian patients with portal hypertension
Researcher Name:Mohamed Karim Farouk Ashour
Supervisor Name(s):Iman Ismail Ramzy
Azza Ahmed El Khawaga
Maissa El Said El Raziky
Pagination:vii,242 p.: ill.; 25 cm
Abstract:Serum NO end product level in cirrhotic patients with portal hypertension and portal hypertensive gastropathy were significantly higher than in the chronic hepatitis and control patients.Among the cirrhotic subgroups,this study showed that the serum level of NO end product were higher in child C patients than child B and child A patients.This denotes that serum NO level increases with the increase in Child-Pugh score.Also there was a statistically significant correlation between NO end product and Child-Pugh score
Date entered : 03-02-2006
Date updated : 04-08-2007
Discussion Date:2001
Cairo University MSc
Call Number:9672 Tropical Medicine
Thesis Title(s):Peritoneo-venous shunt for treatment of intractable ascites
Researcher Name:Mona Mahmoud Hassan
Supervisor Name(s):Fouad Thakeb
Ayman Salah
Eman Medhat
Pagination:133,3 p.: ill.; 25 cm
Abstract:Intractable ascite refractory to medical treatment occurs in about 10of patients with cirrhosis.Peritonea venous shunt are act as an artificial thoracic duct,may models of shunts are used and for example leveen shunt and denver shunt.We used denver shunt for treatment of intractable ascitis in 20 patient with intractable ascites and cirrhosis with flow up period six months.Abdominaly It is found that denver shunt an easy,effective and safe safe method for treatment of intractable ascites.The shunt is easy aplaied and give the patient free mobility and reduction in body weight
Date entered : 03-05-2006
Date updated : 04-08-2007
Discussion Date:2001
Cairo University MD
Call Number:9702 Tropical Medicine
Thesis Title(s):Assessment of gene therapy in Egyptian patients with hepatocellular carcinoma
Researcher Name:Rasha Ahmed Abd Al Aziz
Supervisor Name(s):Ahmed Abd Al- Lateef Abu Median
Hosny Mohamed Salama
Lila Anis Isaac
Pagination:278,4 p.: ill.; 25 cm
Abstract:The aim of this study was to assess the p53 gene expression in Egyptian patients suffering from HCC and to evaluate the safety,biological efficacy,and effectiveness of Ad E 1 B deleted in treatment of Egyptian patients suffering from HCC.
Date entered : 03-06-2006
Date updated : 04-08-2007
Discussion Date:2001
Cairo University MSc
Call Number:9717 Tropical Medicine
Thesis Title(s):The Pattern of colorectal lesions in colonoscopic examinations in the last three years
Researcher Name:Mohamed Ibrahim Seif El-Nasr
Supervisor Name(s):Mohamed Serag El-Din Zakaria
Ashraf Omar Abdel-Aziz
Pagination:v,160,(2)p.: ill.; 25 cm
Abstract:Background and aim of work:The colon is the primary target of many functional and pathological disorders,which may have an acute or chronic presentation.This retrospective study was designed to identify the pattern of colorectal diseases in the Egyptian population in colonoscopic examination during the last 3 years.Patients and methods:The files of 1500 patients who presented to Gastrointestinal Endoscopy Unit,Kasr EL-Aini Hospital during the period from 1998-2000,were retrospectively studied,and their findings were plotted in data sheet for further study.Results:Inflammatory and/or ulcerative colonic lesions were found in (25.1)of cases while (19.7of cases showed colonic polyps.Colonic mass was found in (10.2 of cases and diverticulosis was detected in (3 of cases.Primary piles were found in (17.06of cases while normal colonic mucosa was found in (25of cases.Other colonic lesions as angiodysplasia,colonic stenotic lesions,anal fissure,rectal varices,fistulae,uretero-colic implantation,and foreign body were found in (3.6of cases.Conclusions:Inflammatory and ulcerative colonic lesions are the most common colorectal lesions,followed by colorectal polyps.Colorectal carcinoma is a common malignant neoplasm in Egypt.Colonoscopy is considered a crucial investigating tool in different colorectal diseases as it provides tissue diagnosis by taking a biopsy and allows therapeutic intervention as polypectomy of adenomatous polyps.
Date entered : 03-06-2006
Date updated : 04-08-2007
Discussion Date:2002
Cairo University MD
Call Number:10074 Tropical Medicine
Thesis Title(s):Ultrasonography of hepatoduodenal lymph nodes in patients with chronic hepatitis C with or without cirrhosis
Researcher Name:Shereen Mohamed Shoukry Hunter
Supervisor Name(s):Zakaria Abdel-Latif Salama
Elia Anis Ishak
Mervat M.El-Ansary
Pagination:ix,274,2 p.: ill.; 25 cm
Abstract:The aim of this study is to evaluate the association between hepatoduodenal lymphadenopathy,detected by transabdominal ultrasound (US), and HCV-related chronic hepatitis,and to determine if their presence and size correlate with biochemical and/or histological activity including the presence or absence of liver cirrhosis.The study included 77 anti-HCV antibody positive,HbsAg negative patients presenting to the Tropical Medicine Department,Faculty of Medicine,Cairo University.Sixteen healthy volunteers participated in the study as control subjects.Adequate visualization of the area of the hepatoduodenal ligament was achieved by US in 72 patients (93.51)and in all control subjects (100). Hepatoduodenal lymph nodes were detected in 68 of the 72 patients (94.44)and in 7 of the 16 control subjects (47.75)and the difference was highly significant (p0.01). There was also a highly significant difference in the number and size of lymph nodes between patients and control subjects (p0.01). There was a significant positive correlation between total perihepatic lymph node volume and serum bilirubin level,AST,ALT,ALP and GGT.There was a highly significant difference in the total perihepatic lymph node volume,and a significant difference in the biggest lymph node volume between PCR positive and negative patients.There was also a significant positive correlation between the biggest lymph node volume and the level of viremia.On histopathological examination of liver biopsy specimens,there was a significant positive correlation between total perihepatic lymph node volume and biggest lymph node volume with the grade of activity,and a highly significant positive correlation between the longest axis of the biggest lymph node and the grade of activity.A significant positive correlation was found between lymph nodes size and stage of fibrosis,and the mean total perihepatic lymph node volume and biggest lymph node volume were significantly higher in patients with cirrhosis than those without.It was concluded that hepatoduodenal lymph nodes can readily be detected by transabdominal US in patients with chronic hepatitis C and their enlargement reflects the activity of the liver disease.
Date entered : 03-09-2006
Date updated : 04-08-2007
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